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Pelacarsen Cuts Lipoprotein Apheresis Need in CVD
Added: 3 months ago Source:  Radcliffe CVRM
For patients with elevated lipoprotein(a) [Lp(a)] and established cardiovascular disease (CVD), weekly lipoprotein apheresis (LA) is the only approved treatment, but it represents a significant burden. The Lp(a)FRONTIERS APHERESIS trial investigated whether the investigational therapy pelacarsen could reduce the need for this invasive procedure.¹Mechanism of ActionPelacarsen is a hepatocyte… View more

Cardiovascular Kidney Metabolic
Metabolome-Informed BMI Better Predicts CVRM Risk
Added: 5 months ago Source:  Radcliffe CVRM
A new study has defined a metabolome-informed body mass index (metBMI) that more accurately reflects adiposity and cardiometabolic risk than the traditional BMI calculation.² The findings, published in Nature Medicine, suggest this multi-omic approach could help identify high-risk individuals whose metabolic dysfunction is not captured by conventional measures.¹MethodologyResearchers developed… View more

Cardiovascular Kidney Metabolic

Digital Health
Lp(a) and IL-6 Independently Predict ASCVD Risk
Added: 6 months ago Source:  Radcliffe CVRM
Elevated lipoprotein(a) [Lp(a)] is a known causal risk factor for atherosclerotic cardiovascular disease (ASCVD), with vascular inflammation considered a key mechanism.² A new analysis has investigated whether interleukin-6 (IL-6), a biomarker of inflammation, can help to further stratify cardiovascular risk in individuals with elevated Lp(a). The study analysed data from two large, independent… View more
Andreu Porta-Sánchez
Job title: Cardiologist and Scientist
Personal History Dr Andreu Porta-Sanchez is a Postdoctoral Scientist and a Staff Cardiologist based in Madrid, Spain. He is a specialist in the field of complex arrhythmias including hereditary and genetic arrhythmias, ventricular tachycardia, atrial fibrillation, hisian pacing and cardiac resynchronization. He also specialises in ablation procedures with catheters.2 Academic History… View more
SWEDEPAD 1: Paclitaxel-Coated Devices Show No Benefit in Reducing Amputation for CLTI
Added: 9 months ago Source:  Transcatheter Academy
The use of paclitaxel-coated devices did not reduce the rate of major amputations or death in patients with chronic limb-threatening ischaemia (CLTI) undergoing infrainguinal endovascular revascularisation, according to the results of a large registry-based trial.¹ While drug-coated devices are commonly used in peripheral interventions, their effect on amputation risk has been uncertain.²The… View more

Cardiovascular Kidney Metabolic

Intervention
Multimodal AI Model Offers Deeper Insight into Glycaemic Risk Than HbA1c Alone
Added: 10 months ago Source:  Radcliffe CVRM
Traditional methods for diagnosing and monitoring type 2 diabetes (T2D), such as episodic glycated haemoglobin (HbA1c) assays, may not fully capture the complex, multifaceted nature of the disease. A new study suggests that a multimodal artificial intelligence (AI) approach, integrating data from wearables, genomics, and the gut microbiome, can provide a more detailed and informative phenotype… View more

Cardiovascular Kidney Metabolic

Digital Health
Craig Thompson
Job title: Director
Personal History Dr. Thompson is based in Hartford Connecticut, where he works as Director of Cardiac Catheterization and Interventional Cardiology for Hartford HealthCare. Academic History Dr. Thompson holds an undergraduate degree from the University of Southern Mississippi, a medical degree from the University of Mississippi and a Masters of Medical Science in clinical investigation… View more
Fish Oil Cuts CV Events in Haemodialysis Patients
Added: 7 months ago Source:  Radcliffe CVRM
Patients receiving maintenance haemodialysis have a cardiovascular mortality rate more than 20 times higher than the general population, and many standard preventative therapies have proven ineffective in this high-risk group. The results of a new randomised clinical trial, PISCES, suggest that daily supplementation with fish oil could offer a significant benefit, substantially reducing the rate… View more

Cardiovascular Kidney Metabolic

MI/ACS
Stephanie L Mick
Job title: Director, Minimally Invasive and Robotic Surgery
Personal History Dr Mick is the Director of Minimally Invasive and Robotic Surgery and Associate Professor of Cardiothoracic Surgery at Weill Cornell Medicine. Her interests are in robotically assisted cardiac surgery, percutaneous valve treatments and the team approach in cardiac disorders.1, 2 In her leisure time, she enjoys skiing, travel and music.1 Academic History Dr Mick… View more
Robert Gerber
Job title: Consultant Interventional Cardiologist and Associate Professor
Dr Robert Gerber is a Consultant Cardiologist working in East Sussex, United Kingdom, where he practices at both Conquest Hospital in Hastings and Eastbourne District General Hospital. Born and raised in the UK, Dr Gerber completed his medical education at King’s College London, where he also undertook the MB/PhD programme, distinguishing himself early in his academic and clinical career. Outside… View more