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Body Fat Pattern Predicts CV Ageing Differently in Sexes
Added: 4 months ago Source:  Radcliffe CVRM
While obesity is a known risk factor for premature cardiovascular ageing, the specific impact of body fat distribution has been less clear. A new study analysing data from the UK Biobank suggests that where fat is stored has a significant, and sometimes sex-specific, influence on the biological age of the cardiovascular system.¹This cross-sectional study analysed data from 21,241 participants in… View more

Cardiovascular Kidney Metabolic

Demographic
MC4R Deficiency: Obesity with Lower CVD Risk?
Added: 5 months ago Source:  Radcliffe CVRM
Obesity is a primary risk factor for dyslipidaemia and cardiovascular disease (CVD), but the mechanisms linking weight gain to lipid metabolism are not fully understood. A new study suggests that in a specific genetic form of obesity caused by melanocortin 4 receptor (MC4R) deficiency, individuals may have a more favourable cardiometabolic profile despite their higher body weight.¹This multi-part… View more

Cardiovascular Kidney Metabolic

Inherited and Congenital Cardiac Conditions
UPDATE Trial: Minimally Processed Diet Superior for Weight Loss Within Healthy Eating Guidelines
Added: 8 months ago Source:  Radcliffe CVRM
A diet based on minimally processed foods (MPF) leads to significantly greater weight and fat loss compared to an ultraprocessed food (UPF) diet, even when both diets are designed to meet national healthy eating recommendations, according to findings from the UPDATE trial.¹The consumption of UPF—industrial formulations combining food extracts with additives—has been linked to increased risks of… View more

Cardiovascular Kidney Metabolic

Guidelines & Statements
Metabolite Profile Predicts Future Type 2 Diabetes Risk
Added: 2 months ago Source:  Radcliffe CVRM
The human metabolome reflects a complex interplay of genetic and environmental factors. A large-scale analysis integrating blood metabolomic, genomic, and lifestyle data from ten prospective cohorts has identified a comprehensive profile of circulating metabolites that are associated with the future risk of developing type 2 diabetes (T2D).¹MethodologyResearchers conducted a pooled analysis of 23… View more
Novel Agent Data for Obesity Released at ADA 2024 Scientific Sessions Show Benefits for Glycaemic and Blood Pressure Control
Added: 1 year ago Source:  Radcliffe Cardiology
AUTHOR: David RamseyAmerican Diabetes Scientific Sessions, 23 June 2024 – The data from three studies investigating glucagon-like peptide-1 (GLP-1) receptor agonists and dual GLP-1/GIP (glucose-dependent insulinotropic polypeptide) receptor agonists in patients with obesity was recently presented at a late-breaking session at the American Diabetes Association’s 84th Scientific Sessions in Orlando… View more

Prevention & Chronic Conditions
Metabolome-Informed BMI Better Predicts CVRM Risk
Added: 3 months ago Source:  Radcliffe CVRM
A new study has defined a metabolome-informed body mass index (metBMI) that more accurately reflects adiposity and cardiometabolic risk than the traditional BMI calculation.² The findings, published in Nature Medicine, suggest this multi-omic approach could help identify high-risk individuals whose metabolic dysfunction is not captured by conventional measures.¹MethodologyResearchers developed… View more

Cardiovascular Kidney Metabolic

Digital Health
Olezarsen Cuts Triglycerides and Pancreatitis Risk
Added: 5 months ago Source:  Radcliffe CVRM
For patients with severe hypertriglyceridemia, monthly treatment with olezarsen significantly reduced triglyceride levels and the incidence of acute pancreatitis compared with placebo, according to findings from two pivotal trials, CORE-TIMI 72a and CORE2-TIMI 72b.¹Olezarsen is an antisense oligonucleotide designed to inhibit the production of apolipoprotein C-III (ApoC-III), a key protein in the… View more

Cardiovascular Kidney Metabolic

Prevention & Chronic Conditions